Talbot never got loosened up, and manager Manny Acta pulled him as a precautionary move after the righty had thrown just 14 pitches against the Twins.
"Just before the game, it didn't want to loosen up for me," Talbot said. "I wanted to stay out there, see if I could get it to fire for me. It just wasn't getting there."
Talbot is day to day with right shoulder inflammation, and he will have an MRI on Monday.
"I did see a doctor, but it was nothing extraordinary," Talbot said. "None of us are really worried about the MRI showing anything other than inflammation. It's not a big worry right now."
Talbot walked Denard Span on five pitches to open the game, drawing Acta out of the dugout to check on him.
"Mitch had a tough time getting loose," Acta said. "He's had some rough first innings, but today, he just didn't look right to me.
"First hitter, the ball wasn't coming out of his hand the right way. That's why I went out there."
Talbot shook off Acta's first wave of concern, but after giving up singles to Orlando Hudson and Joe Mauer, Acta pulled Talbot.
"This guy, he's a battler, he was close to fighting me for taking him out," Acta said. "He wanted to pitch through it, stay out there."
Talbot backed up Acta's account of his removal.
"It did feel a little bit better, felt like it was loosening up," Talbot said. "It wasn't to the point where they felt comfortable with it."
Talbot's next start would be this weekend in Kansas City, but it's too soon to tell if he will pitch on schedule. Acta said the team would see how Talbot felt in five days.