Talbot threw around 40 pitches in two innings prior to the Indians' series opener against the Angels, comfortably working through all of his pitches.
"The ball felt to me like it was coming out alright," Talbot said. "The two-seam was running pretty well and sinking."
Cleveland pitching coach Tim Belcher said the plan was to have Talbot throw about 50 pitches in three innings on Monday in Goodyear, Ariz., with one or two Minor League assignments down the road.
Talbot has been on the disabled list since April 17. He was 1-0 with a 1.46 ERA in two starts before the injury.
Asked if he needs more than one start in the Minors before a return was in order, Talbot said it all depends on how his arm responds to the increasing workload.
"It's hard to say," Talbot said. "I feel good, but it's the recovery, so I won't know until after Monday."