Sizemore suffered the same type of injury in May and missed two weeks while on the disabled list for Cleveland. He was injured in the first inning on Sunday.
Sizemore was to travel with the Tribe to Minnesota, where his knee was to be further examined. The Indians recalled left-hander David Huff from Triple-A Columbus.
"It's not the surgically-repaired knee," Acta said. "He had a quick turn around first base and it hurt him a little bit, so we took him out of the game. He's going to be examined [Monday] and we'll know more about it."
In the top of the first inning, Sizemore doubled to left field and made an awkward turn around first base. The Indians indicated that the center fielder tweaked his knee while running during that point of the play.
Sizemore then slid headfirst into second base while legging out the two-base hit off of Baltimore starter Mitch Atkins. The relay throw from left fielder Matt Angle appeared to hit Sizemore in the chest area as he slid.
After being ruled safe, Sizemore quickly shifted to his feet, tossed his helmet to the ground and paced behind second base. After a quick meeting with team trainers, Sizemore did a few test runs in shallow center field.
Sizemore then left the contest and was replaced by pinch-runner Ezequiel Carrera.
The setback comes during a hot streak for Sizemore, who has hit .400 (8-for-20) with two homers, two doubles and four RBIs over his past six games, including Sunday. On the season, the center fielder has hit .234 with 10 homers and 29 RBIs in 60 games for Cleveland.
Sizemore opened the year on the 15-day disabled list while recovering from microfracture surgery on his left knee. He returned in mid-April after a 10-month rehab process, but was sidelined in May with the separate knee issue.