Last season's left knee injury sidelined Sizemore in May and led to microfracture surgery and a grueling 10-month rehab. On Monday in Minnesota, Cleveland placed its star center fielder on the 15-day disabled list with a right knee issue that the club hopes does not include a similar chain of events.
Sizemore, more than anyone else, is hoping the same.
"There's a lot of concern," Sizemore said at Target Field on Monday morning. "I just hope I don't have to go through what I went through last year."
Sizemore was scheduled to fly back to Cleveland, where he will undergo further tests on his ailing right knee. The Tribe recalled left-hander David Huff from Triple-A Columbus to assume Sizemore's spot on the active roster. Huff started Game 1 of Monday's doubleheader at Target Field.
Until the club's medical staff is able to examine the results of X-rays on Sizemore's knee, it will not be clear how much time the center fielder might miss. In May, Sizemore missed two weeks with a bone bruise in his right knee, and that type of timeframe would be a best-case scenario this time around.
"We won't know until the tests and all that kind of stuff," Indians manager Manny Acta said. "We hope that it can only be two weeks like the last time."
Sizemore said this is not like the last time, though.
While legging out a double in the first inning of Sunday's 8-3 loss to the Orioles, Sizemore felt a sharp pain flare up in his knee on his first step beyond first base. On May 10, when Sizemore initially hurt his right knee during a slide into second base, it took a few days for him to realize the severity of his injury.
Sizemore went through a similar ordeal last season. On April 1, he first hurt his left knee during a slide into second base at Dodger Stadium. Sizemore played through the injury and re-injured the knee while diving back into first base at Camden Yards on May 16. In June, he underwent season-ending surgery.
"It's similar," Sizemore said. "It's hard to say whether it's the same. I think it's definitely a concern based on what I went through last year. It's the same area and similar symptoms. It does feel a lot like it, but I can't say for sure.
"It's just frustrating. I don't know how else to put it. It's definitely frustrating dealing with this and being in a similar situation."
The setback comes during a hot streak for Sizemore, who has hit .400 (8-for-20) with two homers, two doubles and four RBIs over his past six games. On the season, the center fielder has hit .234 with 10 homers and 29 RBIs in 60 games for Cleveland, which is also without injured right fielder Shin-Soo Choo (broken left thumb).
For Sizemore, this marks his third stint on the disabled list this season. He opened the year on the shelf before returning from the left knee injury on April 17. Losing him once again to a similar problem is another tough blow for the injury-riddled Tribe.
"He's devastated," Acta said. "He's a guy who really takes it hard when he's not out there with his guys. You've got to have a lot of respect for the guy. He plays through pain all the time. He's done that over the last three years pretty much here.
"It is very hard for him not to be out there with his teammates. And it's hard for us, too. He's such an important part of our team and our clubhouse and everything."