So when he got the call a second time Monday morning, Chisenhall was ready.
"I wasn't quite as panicked [this time]," he said. "The travel was a little bit easier. I didn't have to go across the country. It's definitely a little more laid back [the second time]."
Chisenhall was recalled from AAA Columbus where he was hitting .324 with four home runs and 17 RBIs in 28 games. He spent time on the Minor League DL from April 29 to May 18 with a strained left calf, but was hitting .318 with five RBIs in six games since he returned.
Chisenhall wasted little time adjusting to the big leagues. He got the start as the Indians designated hitter in Monday's 8-5 win against the Royals, and he hit a solo home run in his first at-bat of the game. Chisenhall crushed a 1-1 pitch to the visitor's bullpen down the right-field line to get Cleveland on the board.
"I feel good in the box now," he said after the game. "I faced a few guys out of their bullpen last year, so I was comfortable with their pitching staff."
Chisenhall will take the spot of third baseman Jack Hannahan, who was placed on the 15-day disabled list with a strained left calf on Monday.
"It's never good to have your team beat up," Chisenhall said, "but any way you can get up here, you gotta figure out how to help the team, you gotta fight through those injuries and do what you can to win.
"I know there's a lot of injuries and guys are gonna need to come back at some point, but I'm not really looking at that."
Indians manager Manny Acta plans to use Chisenhall mainly at third base, but occasionally as the designated hitter. Chisenhall was in the lineup at DH and batted seventh Monday afternoon against the Royals.
"I'll find at-bats for him," Acta said. "He's going to play. Right now, with the way our lineup is, he can make some contributions."