One night earlier, Indians manager Manny Acta removed Santana from the club's 8-4 loss due to a lack of hustle.
"I worried," Santana said on Thursday. "He knows, and everybody knows, I want to play every day. After what happened last night, I wasn't sure if I'd play today."
Cleveland's regular catcher was in the lineup as the designated hitter, in the fifth spot of the batting order.
Santana went 1-for-3 in Wednesday's loss, but was pulled from the game after running slowly up the first-base line on a groundout in the sixth inning. He was replaced by backup catcher Lou Marson in the field in the seventh. After the game, Acta said Santana looked "sluggish" in the field.
"We can be beat, but we're not going to be looking beaten," Acta said. "We need full effort from everybody."
Santana said his slow trot up the line stemmed from being upset with himself.
"It's something I'll learn from," he said. "I was running like that because I was mad about the pitch. It was a good pitch and I got a ground ball to third base. I was so mad at myself. I want to help the team."
Santana has been on an upswing of late, hitting .282 with a .402 on-base percentage, eight home runs, 10 doubles and 27 RBIs in his last 47 games, entering Thursday. In his previous 67 games, the catcher hit .219 with a .336 OBP, five homers, 12 doubles and 29 RBIs for Cleveland.
The catcher's recent improvement, however, has done little to help the team's place in the standings.
"The team is in a bad situation," Santana said. "But I'll be all right. I'll be giving everything 100 percent."