Chisenhall started at third base and hit sixth, going 1-for-3 with a walk. It was his first game for Cleveland since he incurred a broken right forearm after being hit by a pitch from the Orioles' Jake Arrieta on June 29.
Indians manager Manny Acta said Chisenhall, who was activated from the 60-day disabled list Sunday, will be worked into the lineup gradually. Acta said Chisenhall likely would rest Tuesday at Texas.
He went 2-for-10 with two RBIs in three rehab games with Double-A Akron last week.
"I think the last few weeks of the season are probably going to dictate what we want to see out of him," Acta said. "First of all, he hasn't had that many at-bats. He's coming from a broken arm, so we're going to work him slowly. It's nothing that is set in stone right now, how many at-bats [he'll get]. We need to see how he progresses throughout the first week."
Chisenhall began the season with Triple-A Columbus, hitting .324 in 28 games before being promoted. He hit .278 with three home runs and nine RBIs in 24 games for the Indians before the injury.
"He feels pretty good," Acta said. "When he was down there [with Akron] he felt he was ready to go, like he wasn't limited or anything right now. But I think we saw last year when [Asdrubal] Cabrera bounced back from the broken wrist, a lot of times it takes those guys some time to get the strength back. So that's something to consider."