After the Reds tied the game in the bottom of the inning on Miguel Olivo's bases-loaded walk, the Indians rallied in the second against Alfredo Simon. Michael Brantley hit a leadoff double to right field and scored on Lonnie Chisenhall's lined single into center field. With two outs, Cabrera hit a two-run single off of the right-field wall.
Normally Cincinnati's long reliever, Simon pitched 1 2/3 innings in the start, which was a tuneup for his participation in the World Baseball Classic with the Dominican Republic. Three of the four runs he allowed were earned with five hits, a walk and a strikeout.
In the second inning against Indians projected No. 3 starter Brett Myers, Shin-Soo Choo reached on a two-out throwing error by Cabrera and scored on Brandon Phillips' double down the left-field line.
Myers worked two innings, allowing two runs (one earned) on three hits with a walk and two strikeouts.
"I felt fine," Myers said. "I'm just trying to work on my fastball location and my changeup. I'll throw the other stuff later. I need those two pitches right now. The changeup is my fourth pitch, so I want to work on it and make sure it's there for the season."
Olivo drove in his second run with a sacrifice fly against Edward Paredes in the third inning.
Called on to replace Nick Christiani with two on in the top of the fourth, lefty reliever Wilkin De La Rosa walked his first two batters, including Jesus Aguilar with the bases loaded. Following a Mike McDade sacrifice fly, Ben Francisco hit an RBI double.
Indians closer Chris Perez entered in the bottom of the fourth and worked a scoreless inning with a hit and a strikeout.
Against Indians pitcher Corey Kluber with one out in the fifth, Yorman Rodriguez smacked a two-run double to left-center field to make it a two-run game. In the sixth inning against Reds prospect Daniel Corcino, Cord Phelps hit a 2-1 pitch for a solo home run to left field.
Second baseman Ryan Raburn, seeking a roster spot with the Indians, belted a pair of two-run homers late to help the Indians secure a 2-0 start to Cactus League play.
"You've got to respect that this is like the regular season for these guys," Indians manager Terry Francona said after Saturday's game. "[Raburn] understands that. It's the second game, but it's still nice to see. He's taken a couple of nice swings. It's fun to watch."
Up next: The Indians will take on the Reds at home and the Brewers on the road in a pair of split-squad contests Sunday at 3:05 p.m. ET. Right-hander Zach McAllister (Cleveland's projected fourth starter) is slated to make his spring debut against Cincinnati at Goodyear Ballpark. Righty Daisuke Matsuzaka, who is competing for the fifth spot in the rotation, is also expected to pitch. Against Milwaukee at Maryvale Baseball Park, rotation candidates Carlos Carrasco, Scott Kazmir, Trevor Bauer and David Huff are all scheduled to throw.