Because of a back injury to shortstop Asdrubal Cabrera, who was back in the lineup after missing a week, Francona has not been able to set up his regulars, not until Saturday.
"This is it unless something happens on that flight," Francona said. "What do I like about it? It has balance, speed and length to it. We have switch hitters. We have left-handed hitters. We have right-handed power. Now we have to go see how this lineup is going to do.
"A guy like Mark Reynolds sitting down there in the seven hole, if he goes through periods where he's missing, he's not hitting cleanup. He's going to have so many opportunities to drive in runs with [Michael] Brantley and [Carlos] Santana hitting in front of him. I think that puts him in a good position."
Veteran Indians right-hander and offseason free-agent signee Brett Myers set down what amounted to a Triple-A Louisville lineup for the Reds, pitching five innings, allowing a run on three hits and striking out three. He earned the win.
Santana hit a homer for the Tribe, leading off the fourth inning against Reds right-hander Armando Galarraga, who went four and was touched up for two runs on five hits with four walks and a strikeout. Galarraga was tagged with the loss.
The Indians' regulars started to leave the game in the second inning. Meanwhile, the Reds regulars' were all in the starting lineup downtown at Chase Field, where Dusty Baker managed the club against the D-backs. Opening Day is at home for the Reds on Monday.
In Goodyear, the Reds were managed by veteran Jim Riggleman, who has been elevated in the organization to the Louisville job this year.
Their only run against Myers was generated by speedster Billy Hamilton, who opened the fourth with a single, stole second and came around to score on a pair of infield grounders.
The Indians also had a homer in the game from outfielder Matt Carson, his fifth of the spring.
Up next: The Indians fly to Toronto, where they will take a day off Sunday and then work out Monday before opening the season Tuesday night at Rogers Centre against the Blue Jays. The team is healthy, and right-hander Justin Masterson is slated to go against knuckleballer R.A. Dickey for the Jays.