"I'm symptom free," Pestano said. "It was brutal watching these guys on TV. It's tough. You kind of almost feel forgotten a little bit when you're not a part of the team."
Pestano takes the spot of left-handed reliever Nick Hagadone, who was optioned to Triple-A Columbus on Thursday.
Pestano last pitched for the Indians on April 28. In eight games this season, he's compiled a 2.25 ERA and struck out eight while walking four. Cleveland manager Terry Francona said Pestano would move right back into his eighth-inning role.
"If there's any rust, we'll let him shake it off," Francona said. "You could throw him in a different inning. His effort level is going to be the same. And he's been doing this long enough now, we'll just throw him right back in."
On Wednesday, Pestano notched a strikeout in a scoreless inning for Class A Lake County.
He was all smiles in his return to Cleveland.
"When you're not contributing to the team, you kind of don't feel like you're doing much for the team," Pestano said. "It'll be nice to go back out there and get outs for us."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. Mark Emery is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.