Santana's teammates were disappointed that his great personal moment came within a 6-3 loss in the opener of this three-game series. The three-run shot off Tyler Skaggs gave Cleveland a 3-1 lead, but the Angels scored five unanswered runs off Tribe righty Justin Masterson to deal the Indians the loss.
"I was hoping we could be victorious," Masterson said, "so we could do nothing but talk about Santana and how great he did right there. That was big. He's been struggling a little bit. To be able to do that, it was big time. Unfortunately, with the loss, it kind of overshadows how good that could've been.
"Hopefully that'll keep him going on a streak over the next few days and few weeks."
The home run snapped an 0-for-12 slump for Santana, who finished 2-for-4 for his first two-hit showing since April 6 against the Twins. Heading into Monday's game, the third baseman had hit just .052 (3-for-58) in his previous 16 games. The three RBIs he collected against the Angels were as many as Santana had in his previous 23 games combined.
On the season, the switch-hitting Santana has hit .140 with two home runs, six RBIs and 21 walks in 25 games for Cleveland.
Through it all, Indians manager Terry Francona has kept Santana in the cleanup spot.
That has meant a lot to Santana.
"Tito supports me and gives me confidence," Santana said. "He hasn't changed anything with me. I feel great. Tito is a good manager. He has experience and he knows what kind of players that he has. I feel so great, because Tito supports me and he gives me energy day by day."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. This story was not subject to the approval of Major League Baseball or its clubs.