With two outs and the contest in a scoreless tie, Santana narrowly beat the throw and tag by shortstop Asdrubal Cabrera by sliding back into second. Francona chose to challenge the ruling to be safe, but the play stood as called after a brief review.
Francona has had two of seven replay challenges overturned this season.
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. This story was not subject to the approval of Major League Baseball or its clubs.